Wilhelm Johannsen, the Danish botanist who coined the term "gene," showed the value of inbreeding to fix characteristics, and Little applied that idea to mice. In 1909, he produced the first inbred ...

At the University of Aarhus animal facility, we observed sporadic cases of sudden death of inbred, mutant and transgenic lactating female mice. The cases were dispersed among all murine genotypes ...

Unlike inbred lab mice commonly used in research, most scientists studying Peromyscus either capture them from the wild or use mice derived from lab colonies that were initially started with ...

We identified allelic variation in the mouse α5 and α7 genes (Chrna5 and Chrna7) between two inbred mouse strains (C3H and DBA/2). Traditional backcross breeding strategies were used to generate ...

A breakthrough was achieved in 1909 when researchers managed for the first time to mate mice with each other over many generations. The animals from this inbred line were homogeneous, so that the ...

Mayo Clinic's Precision Mouse Engineering Core in Minnesota produces CRISPR/Cas9-mediated knockout and point mutant mice for researchers.