Expert Rev Clin Immunol. 2013;9(3):211-216. Atopic dermatitis is a chronic inflammatory skin disease that commonly begins in early infancy, runs a course of exacerbations and remissions and is ...

IgE is transported to mucosal tissues by CD23 and is also synthesized by the resident B cells. Its concentration is maintained in the tissue by the number of mast cells that express FcεRI at high ...

The relationship between food allergies and chronic illness represents one of the most significant yet underappreciated ...

By simulating allergic reactions in a controlled environment, the test provides functional insights into IgE-mediated allergies. In the Hoxb8 MAT, mast cells are exposed to serum samples from ...

Histamine makes lots of changes in your body. It adjusts your blood vessels and tissues so more immune cells can rush to the area. It makes a bunch of mucus. It tells the muscles in your airways, ...

WATERTOWN, Mass.--(BUSINESS WIRE)--Seismic Therapeutic, Inc., the machine learning immunology company, today announced the presentation of preclinical data for its immunoglobulin E (IgE) protease ...

Researchers from Shenzhen University have evaluated the potential antiallergic effects of the histone acetyltransferase KAT6A inhibitor WM-1119 on IgE-mediated mast cell activation and allergic ...

BLU-808 achieved dose-dependent serum tryptase reductions exceeding 80 percent, reflecting evidence of mast cell target engagement. BLU-808 had a half-life supporting once-daily oral dosing and ...

Across the UK, more and more people are developing allergies each year. They can range from inconvenient allergic reactions to pollen, pets or household dust, to severe reactions that can be life ...

An allergic inflammatory response is a sequential interaction between various inflammatory and structural cells through their chemical messengers, which together lead to symptoms of allergy.