Homologous recombination plays essential roles in the ... In fact, many of the proteins involved in the sensing, signaling and repair of DSBs were identified through studies of inherited cancer ...

During the DNA damage response (DDR), repair proteins such as the E3 ubiquitin ... and PIAS4 causes a decrease in DSB repair by homologous recombination and non-homologous end joining, indicating ...

How do we find out which protein ... DNA Repair (Amsterdam) 7, 788–800 (2008). Rothstein, R. et al. Concerted deletions and inversions are caused by mitotic recombination between delta sequences ...

We are interested in homologous recombination not only because of the intellectual challenges it presents, but also on the insights it may bring to the mechanism of the repair of double ... by the ...

Common to these genomic integrity pathways is eventual repair by homologous recombination, a process that has been ... by cryo-electron microscopy are helping scientists learn how proteins and DNA ...

Researchers developed a biomimetic nanovesicle that crosses the blood-brain barrier, degrades DNA repair proteins, and ...

such as the processing of broken DNA for repair by homologous recombination. We are also interested in understanding the structural basis for the activation and catalytic modulation of helicase ...

RBM39 is an RNA-binding motif protein overexpressed in multiple cancers. Leveraging deep expertise in ubiquitin biology and E3 ligase structure, SEED developed a novel RBM39 degrader with significant ...