Homologous recombination plays essential roles in the ... In fact, many of the proteins involved in the sensing, signaling and repair of DSBs were identified through studies of inherited cancer ...

Copy number variants (CNVs) arise by homologous recombination (HR ... cells could cause non-homologous repair because of a downregulation of HR proteins induced by stress. Models are presented ...

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

Mol Cell Biol. 1998;18:93-101. Johnson RD, Liu N, Jasin M. 1999 Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature. 1999;401:397-399.