The proteins responsible for radiation ... and are all implicated in checkpoint regulation and DSB repair, such as homologous recombination (HR). We measured the ability of several NBS1 mutant ...

Homologous recombination (HR ... perform supplemental functions in conjunction with the core proteins. The inability to properly repair complex DNA damage and resolve DNA replication stress ...

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

The next steps in homologous recombination seemed blocked ... the heterochromatin domain in order to load Rad51 protein and complete the repair process. "There are a lot of moving parts here ...

Unlike its DNA repair role in somatic cells, homologous recombination has a distinct ... the introduction of double-strand breaks into chromosomes by the Spo11 protein to promote recombination between ...

Wang and Dr. Ting-Fang Wang at the Institute of Biological Chemistry, Academia Sinica(IBCAS), has discovered that the RecA family recombinases function as a new type of rotary motor proteins ... 2007.

where it prevents other proteins from further degrading the break site to repair by homologous recombination. "Double-strand breaks that are not protected by the RIF1 protein complex are ...

using part of the homologous-recombination machinery in conjunction with more than 13 Fanconi's anemia proteins and one of the nucleotide-excision repair endonucleases. 34–36 Damage to DNA that ...

the paralogues and complex repair the damage by filling in the missing pieces in a process called homologous recombination. "Now that we understand what the proteins do, we can perhaps tailor ...

Homologous recombination deficiency (HRD ... prevent the body from producing proteins that help repair breaks in DNA. This leads to an accumulation of mutations, ultimately causing cancer.

Homologous recombination plays essential roles in the ... In fact, many of the proteins involved in the sensing, signaling and repair of DSBs were identified through studies of inherited cancer ...

Wang and Dr. Ting-Fang Wang at the Institute of Biological Chemistry, Academia Sinica(IBCAS), has discovered that the RecA family recombinases function as a new type of rotary motor proteins ... 2007.