Hippocampal neurons in the heterozygous mice had reduced short- and long-term potentiation. Shen and Kelleher proposed a model in which PS1 mutations prevent the enzyme from cleaving crucial ...

A mouse model harboring this mutation recapitulates the immunohistochemical ... and dots indicate heterozygous carriers. Panel C shows a schematic representation of a dystroglycan mutant protein ...

Instead, the researchers used a leukemia mouse model with a defective genetic proofreading system called Polg, which gradually accrues mtDNA mutations. By disrupting Polg’s proofreading function in ...

That may be because most mouse models of Alzheimer's disease harbor the Swedish mutation. This has so far hindered efforts to study the beneficial effects of the Icelandic mutation. Now ...

The method can correct heterozygous mutations using two mechanisms: multiple nicks induced by Cas9 nickase and a homologous chromosome as an endogenous repair template. The researchers suggest ...

People have two MTHFR genes, inheriting one from each of their parents. Mutations can affect one (heterozygous) or both (homozygous) of these genes. There are two common types, or variants ...

However, a team from the University of Tsukuba have now generated the first mouse model carrying a disease-associated mitochondrial mutation and have shown that the resulting disease is caused by ...

A new model mouse for the neurodegenerative disorder has helped uncover the protective mechanism of a genetic mutation Figure 1: A micrograph showing inflammatory responses in the cortex of the new ...