These ES cells are heterozygous for the knockout mutation. Although these cells will grow and divide in culture, they cannot form an embryo that will develop into a mouse on their own. Step 4 ...

CHAMPAIGN, Ill. — A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct ...

The mice with mutations analogous to those in the human patients also showed schizophrenia-associated behaviors. To further ...