After discovering the signaling pathway, the scientists designed a ... proved the viability of the pathway but also prevented liver fibrosis—too much collagen in the liver—without causing ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...

One of the reasons that fibrosis can be difficult to effectively treat may be explained by the multiple profibrotic disease pathways that reinforce each other. Blocking Piezo2 signaling to prevent ...

Tribune’s lead candidate, TRX-44, mimics how CCN5 stops fibrosis signaling and is being developed first to treat the chronic lung disease idiopathic pulmonary fibrosis. The small team in Oslo ...