There are three key aspects to genetic disease associations: comprehensive variant discovery, accurate allele-frequency determination, and an understanding of the pattern of normal variation and ...

At this more extreme boundary, the relative allele frequency may differ dramatically from those at the opposite boundary. Distribution is one way that genetic variation can be preserved in large ...

Genetic variation is usually expressed as a relative frequency, which means a proportion of the total population under study. In other words, a relative frequency value represents the percentage ...

Scientists at the Institut Pasteur and McMaster University have discovered that the evolution of a gene in the bacterium that ...

Genetic cluster membership was ... A negative correlation was observed between minor allele frequency and site coverage depth. Per-sample minority variation was associated with MTBC lineage ...

The five highest-frequency variants account for ... powered for ruling out pathogenicity even for rarer variation. We hypothesized that genetic variants that are common among black Americans ...

Studies of genetic variation usually focus on groups—Han ... are more likely to mate inside the group than outside, the frequency of particular genetic markers within that group can become ...

Materials & methods: Four HapMap tagging SNPs covering the common genetic variation in SGLT2 (r 2 > 0.8 and minor allele frequency >0.01) were genotyped for subsequent association studies on BMI ...

A higher level of diversity in these regions suggests more genetic variation in genes that encode ... allowing bad mutations to increase in frequency or maintain high frequencies of good mutations.