Discover how researchers at the University of Pretoria have identified a gene that may transform our understanding of obesity ...

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

geneticists can generate knockout mice in which the mouse counterpart of a human gene of interest is deleted or disrupted. The term "knockout mouse" may at first conjure images of a mouse boxing ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

The Ragon Institute’s Vinay Mahajan and colleagues previously observed a number of immune system defects in mice engineered to have a defective Siae gene, including a decrease in marginal zone B cells ...

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

Boosting vitamin B12 levels can protect against acute pancreatitis by energizing pancreatic cells and preventing tissue ...

Estrogens are known for their role in reproduction, but a new study from Fujita Health University, Japan, reveals that neuroestrogens—estrogens produced in the brain—play a key role in appetite ...

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...