Known off-label uses where doctors prescribe gabapentin include as a treatment for hot flashes, restless leg syndrome, mood disorders, anxiety, and to diminish nerve pain related to diabetes or ...

Primary and review articles published in English were identified by a MEDLINE (1966-June 2003) search using the MeSH terms "hot flashes," "hot flushes," "menopause," and "serotonin reuptake inhibitor.

Gabapentin (900–2,400 mg per day) decreased hot flashes by 35–38% when compared with the corresponding placebo group. The analysis by Loprinzi and co-workers supports the notion that ...