April 15, 2007 (Vol. 27, No. 8) New Technologies and Approaches Facilitate the Discovery of Ligands G protein-coupled receptors (GPCRs) are transmembrane proteins that transduce an extracellular ...

For both GPCR- and non-GPCR-targeted drugs, CRISPR has been applied across the drug development pipeline from early target identification and candidate screening through lead optimization and pre ...

Writing in Nature, Chen et al. 1 report the first structure of a GPCR–GRK complex: the light-responsive receptor rhodopsin bound to its specific kinase, GRK1 (also known as rhodopsin kinase).

Activation of classical second messenger cascades cannot fully explain the recently appreciated roles of heptahelical, or G-protein coupled receptors (GPCRs), in stimulation of mitogen activated ...

AbbVie and Sosei Heptares will initially focus on developing up to three GPCR-modulating small-molecule drugs to the point at which they are ready to start clinical trials in humans, whereupon ...

Although G protein-coupled receptors (GPCRs) are crucial to the regulation of most functions in the human body, very little is known about how they work. In a new study, researchers at the Biozentrum ...

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DiscoveRx® acquired the KINOMEscan kinase screening services division from San Diego-based Ambit Biosciences. With this deal DiscoveRx says that it now offers over 400 functional cell-based GPCR ...

A large fraction of existing drugs target various GPCRs. While exploring the mechanism of regulating immune cell migration, this team identified a protein complex consisting of copper metabolism MURR1 ...

CHICAGO, December 27, 2024--Exicure, Inc. Partners with GPCR Therapeutics Inc. to Fuel New Growth in Biotech ...