G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Scientists have discovered how chemokines and G protein-coupled receptors selectively bind each other to control how cells move.

G-protein coupled receptors regulate hormone secretions in the pancreas. Learn how the complex signaling features of these receptors are illuminating diabetes research. Diabetes results from ...

GPR6 is an orphan G protein-coupled receptor primarily expressed ... researchers determined the receptor's structure in different states, including when it's inactive, partially active, and ...

Scientists from St. Jude Children's Research Hospital and the Medical College of Wisconsin have created a data science ...

GenAI offers a realistic path forward in tackling previously undruggable targets, with the potential to reshape the entire ...

"The key to understanding this family of proteins has been the determination of their molecular structure. "Now, half of all medications achieve their effect through G-protein-coupled receptors. It is ...

G protein-coupled receptors (GPCRs) are involved in many diseases, yet raising therapeutic antibodies against them is notoriously difficult because the transmembrane receptors contain only short ...

Structure Therapeutics Inc.’s GPCR share price has surged by 29.14%, which has investors questioning if this is right time to sell.

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their ...