The American doctor has revealed that enigmatic DNA circles are present in more than half of patients with highly aggressive ...

Extrachromosomal DNAs (ecDNAs) encode oncogenic driver proteins, regulatory elements, immunomodulators, and genes of yet-unknown oncogenicity (Panel A). They exist as circular pieces of DNA in the ...

the extrachromosomal DNA (ecDNA) found in some cancer cells is not always split evenly. Lacking centromeres, these circular bits of DNA are often unevenly parceled to daughter cells. Some daughter ...

“We see firsthand that even when two patients both have MYC on ecDNA, the structure of that circular DNA can ... that organoids bearing MYC on extrachromosomal DNA could shift their dependency ...