Extrachromosomal DNAs (ecDNAs) encode oncogenic driver proteins, regulatory elements, immunomodulators, and genes of yet-unknown oncogenicity (Panel A). They exist as circular pieces of DNA in the ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes ...

Thus, they are referred to as extrachromosomal circular DNA. But scientists still know relatively little about their function, mainly because they have lacked technologies for a more detailed ...

Now, researchers from UC San Diego and their colleagues have found that HPV DNA hybridizes with human DNA genes in oropharyngeal cancer cells, forming extrachromosomal circular DNA (ecDNA) that ...

Lukas Chavez uses multiomic techniques to study how extrachromosomal DNA (ecDNA ... researchers now know that these tiny bits of circular DNA play a big role in cancer outcomes. In this episode, Niki ...

the extrachromosomal DNA (ecDNA) found in some cancer cells is not always split evenly. Lacking centromeres, these circular bits of DNA are often unevenly parceled to daughter cells. Some daughter ...

Extrachromosomal circular DNA (ecDNA) occurs frequently across many cancer types, and while they have been known about for decades, Boundless Bio claims it is the first company to bring a therapy ...

A method for parallel sequencing of single-cell extrachromosomal circular DNA (ecDNA) and full-length mRNA transcriptomes has enabled new insights into the roles of ecDNA in cancer progression, ...

EcDNA is made up of small, circular segments of DNA that form outside of chromosomes within the cell, and is frequently found in cancer cells. It has been shown to elude the immune system and ...