The enzymes of hydrogenosomes are not unique to these anaerobes. They are found also in the mitochondria, the cytosol, or even the plastids of other eukaryotes (Figure 1). A fourth category of ...

When the mechanisms that replicate or repair mitochondrial DNA (mtDNA) fail, it can cause a wide range of syndromes for which ...

“What’s striking about this study is that this gene, tamas, encodes a subunit of the mitochondrial DNA polymerase, which is the enzyme responsible for replicating the mtDNA,” said Damian Dowling of ...

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt ...

Researchers at the University of Gothenburg have identified a small molecule, PZL-A, that restores function in the defective ...

A research team from the International Research Center for Medical Sciences (IRCMS) at Kumamoto University has identified a ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

Mitochondrial diseases are often caused by mutations in enzymes required for the expression of the second genome in our cells, the mitochondrial DNA. The genes encoded in the mtDNA are strictly ...