This enzymatic method enables highly specific and complete 1:1 protein conjugations with small molecules, solid supports, and other proteins, offering broad applicability across diverse biochemical ...

“The discovery of a protein with a new type of enzymatic activity that has never before been characterized is a significant scientific accomplishment, and the potential that it is a therapeutic ...

Scientists have long struggled to target proteins that lack defined structure and are involved in cancer, neurodegenerative disorders like Parkinson's disease, and other serious illnesses.

"Each round of modifications made the enzyme more specialized," he says, "until it could selectively degrade α-Synuclein while leaving other proteins untouched." When tested in human cells ...

A research team from the International Research Center for Medical Sciences (IRCMS) at Kumamoto University has identified a ...

have identified new inhibitors of the enzyme human 15-lipoxygenase-2 (h15-LOX-2). This protein plays an important role in inflammatory and metabolic processes and contributes to cellular homeostasis.

"Each round of modifications made the enzyme more specialized," he says, "until it could selectively degrade α-Synuclein while leaving other proteins untouched." When tested in human cells ...