Endothelial cell inflammation causes vasodilation through ... Inflammation and coagulation are closely linked in sepsis. Inflammatory mediators generate tissue factor expression and initiate ...

This state is mediated by a receptor on endothelial cells called Tie2. Under normal conditions, ANGPT2 prompts Tie2 to produce an anti-inflammatory response. However, these conditions are reversed ...

one that helps mitigate sepsis: promoting stability of the endothelial barrier by restoring the tight junctions between endothelial cells that ordinarily regulate molecule transport and leakage.

CD47-amyloid-β-CD74 signaling is a key driver of adaptive immunosuppression in sepsis, suppressing B cells and impairing ...

whereas tools for vascular stabilization and prevention of capillary leakage in sepsis are scarce (Nat Rev Drug Disc, 2017, review). Integrins couple endothelial cells to the underlying vascular ...