Syntichaki et al. used C. elegans having different mutated aspartyl proteases, and treated them with calpain inhibitors. They observed that neuronal degeneration inflicted by various genetic lesions ...

Caenorhabditis elegans is a species of soil-dwelling nematode (roundworm) used as a model organism in molecular genetics and developmental biology. It is predominantly hermaphroditic (can self ...

Biologists' favorite worm gets viruses: Finding means C. elegans may aid studies of human infections Date: January 26, 2011 Source: Washington University School of Medicine Summary: A workhorse of ...

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates that are involved in proliferation, apoptosis and migration ...

C. elegans has high-level behavioral phenotypes such as chemotaxis, electrotaxis, and learning and memory, making it a unique value in biology genetics. Otherwise, C. elegans has transparent ...

Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans. Immunity, 2023; DOI: 10.1016/j.immuni.2023.01.027 ...

Researchers have identified an endogenous insulin antagonist, INS-7, in Caenorhabditis elegans that modulates fat loss by inhibiting a gut-to-brain signaling pathway involving the neuropeptide FLP-7.

Calpain 3 was analyzed by western blot (Figure 2) using mouse anti-human calpain 3, clone 12A2 (Novocastra) recognizing the full size and 60 kDa bands and clone 2C4 recognizing full size and 30 ...

“It deserves all of the honor, but of course it will not be able to share the monetary award.” Dr. Brenner, often thought of as the father of C. elegans research, is the closest thing there is ...

Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of ...