Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature , 2011; DOI: 10.1038/nature10084 Cite This Page : ...

A link between telomeres and a molecular signaling cascade called the Wnt pathway has been identified by researchers, which may point to a treatment option for dyskeratosis congenita patients.

Gene testing revealed a pathogenic DKC1 mutation (A353V), and over the following 10 years he developed esophageal and urethral strictures, retinal hemorrhages and osteopenia. At 10 years of age ...

Dyskeratosis congenita is an inherited human disease from which sufferers die between the ages of 16 and 50. Problems tend to occur in tissues in which cells multiply rapidly — skin, nails, hair ...

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure. Typically diagnosed in childhood, the disorder causes stem cells to fail ...

Telomeres shorten steadily as we age, but in certain medical conditions like dyskeratosis congenita, the process is accelerated. "Your telomeres determine your lifeline; how long they are ...

New York, January 10, 2003 -- A rare genetic syndrome, Dyskeratosis Congenita (DC), may hold the key to understanding a mechanism that causes premature aging and cancer. Recreating DC in ...

The study evaluated a reduced-intensity conditioning regimen without total body irradiation for alloHCT in DC/TBD patients. Non-TBI patients showed similar graft failure, GVHD, and overall ...

“Genetic lesions that reduce telomerase activity inhibit stem cell replication and cause a range of incurable diseases, including dyskeratosis congenita (DC) and pulmonary fibrosis (PF ...

didn't get to do either. But those who loved her, who watched her battle dyskeratosis congenita, a rare genetic condition that affects just one in one million people, said she lived courageously ...

Telomeres shorten steadily as we age, but in certain medical conditions like dyskeratosis congenita, the process is accelerated. “Your telomeres determine your lifeline; how long they are determines ...