There is some good news: the development of JAX diversity outbred (J:DO) mice. These mice are better models of human genetic diversity, have much more uniformly and widely distributed genetic ...

Like humans, each Diversity Outbred mouse is genetically unique, and the extent of genetic variability among these mice is similar to the genetic variation seen among humans. Using these mice, ...

Mice and humans share about 95 percent of ... In 2009 Churchill's lab started the Diversity Outbred mouse population with breeding stock selected from the Collaborative Cross project.

Scientists relied on Diversity Outbred mice, a population from eight parents created by The Jackson Laboratory to better reflect genetic diversity in humans. The Dlgap2 study involved 437 mice ...

Mice and humans share about 95 percent of ... In 2009 Churchill's lab started the Diversity Outbred mouse population with breeding stock selected from the Collaborative Cross project.

Al-Barghouthi et al, Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength, Nature Communications (2021). DOI: 10.1038/s41467-021-23649-0 ...

The current study's researchers investigated the effects of both CR and IF on the health and lifespan of female diversity outbred (DO) mice. Notably, DO mice are genetically diverse, which allows ...

However, these models are not suitable for studying the impact of genetic diversity on the clinical course of Orientia tsutsugamushi infection. Susceptibility of outbred mice to Orientia ...

the mice that produce basic scientific breakthroughs will require vast DNA diversity and much more genetic manipulation.