This study highlights the importance of proteins that are involved in the regulation of the actin cytoskeleton, revealing fundamental roles for HEM1 in both innate and adaptive immune cells.

Marcelo Marucho, an associate professor in the UTSA Department of Physics and Astronomy, studies, in particular, the cytoskeleton’s actin filaments and microtubules for the past 4 years. He works to ...

The paper S. Kaur et al., “An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis,” eLife, 3:e00829, 2014. For decades, scientists observed clathrin-mediated ...

The actin cytoskeleton provides force for dynamic cellular processes, such as motility, morphogenesis, cell division, endocytosis, and phagocytosis. The organization and dynamics of actin filaments ...

Since a tight regulation of cellular mechanics is critical to various physiological processes, and a deregulation of actin network ... the nanoscale organisation and dynamics of the actin cytoskeleton ...

Disorganization of the actin cytoskeleton induces alterations of intestinal barrier functions, leading to passage of fluids into the intestinal lumen, but to a lesser degree. Intracellularly ...

In our lab, we aim to elucidate the interplay of clathrin structures with the actin cytoskeleton and cellular adhesions. This work enables us to apply our findings to understand disease processes and ...