In the Season 14 premiere of Supernatural, Jensen Ackles is possessed by Michael and doesn't appear as Dean Winchester.

The CW star talks season 10 myth arc and looks back on his many variations of Dean Winchester ... first born and big brother — often overprotective, trying to walk in his father’s shoes ...

It's quite difficult to imagine an episode of Supernatural without the main protagonists, Dean and Sam Winchester.

While Sam and Dean Winchester have pretty awesome first introductions in the pilot episode, plenty of other characters create lasting impressions with notable debuts. Every so often, Supernatural ...

EXCLUSIVE: Supernatural, one of the most important series in the history of the CW, is eyeing a comeback with a new iteration with prequel The Winchesters, centered on Dean and Sam Winchester’s ...

But which of the two Ackles characters — one who did everything his demon-hunting father John Winchester (Jeffrey Dean Morgan) asked of him and his brother, Sam (Jared Padalecki), and the other ...

Sam and Dean Winchester's 15 long years of saving people and hunting things together came to an end that was pretty definitive, and likely to be divisive. Picking up on where the penultimate ...