Their experiments found that diabetic (db/db) mice with low levels of two related amino acids, serine and glycine, were at higher risk for peripheral neuropathy.

Talchai and colleagues then described evidence of beta-cell dedifferentiation and loss of Foxo1 activity in two other mouse models of type 2 diabetes (leptin-receptor–deficient db/db mice and ...

Pancreatic islet from a diabetic db/db mouse treated with PX-478, showing the endocrine beta cells (cyan), alpha cells (green), and delta cells (red).

The untreated diabetic mice excreted nearly 10 times more albumin than the db/m mice, ... However, the treated diabetic mice, who were fed the diet with chromium picolinate, ...

The scientific team also demonstrated the therapeutic effects by experimenting on diabetic (db/db) mice. Treatment began by applying the device near the abdomen of the db mouse.

These results show that the human GLP-1 coding sequence of RJVA-001 demonstrates potency on both glucose lowering and weight loss in db/db mice, the standard rodent T2D efficacy model used for ...

When wild-type animals are made diabetic, all four of the pathways are activated in tissues where diabetic complications occur. In contrast, when MnSOD transgenic mice are made diabetic, there is ...

“By licensing this new technology to GATC DB Care, we are allowing this platform to reach its full valuation potential in the US diabetes market, which accounted for $237 billion in direct ...

These results show that the human GLP-1 coding sequence of RJVA-001 demonstrates potency on both glucose lowering and weight loss in db/db mice, the standard rodent T2D efficacy model used for ...