Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, ...

For all six proteins, three 'loop' regions are most important for sequence specific DNA binding. The first of these is a segment between the first two strands of the Ig-fold, referred to as the A ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

The results depicted in Figure 1 also consider the role of zinc (Zn) in Sp1-DNA binding. Sp1 is a protein that has multiple zinc-finger motifs, or regions known to bind to zinc; however ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

Researchers at the University of Southern California have unveiled a groundbreaking AI model designed to predict the accuracy of protein-DNA binding. Named Deep Predictor of Binding Specificity ...

A Bristol Myers Squibb Co. patent detailed new substituted phenyl oxooxazolyl piperidine dione molecular glue degraders acting as DNA-binding protein Ikaros (IKZF1), zinc finger protein Helios (IKZF2) ...

they found that it generated enough protein to protect cells’ DNA from radiation-induced damage. If developed for use in humans, this approach could benefit many cancer patients, the researchers ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

How a crucial DNA repair protein works -- and what it means for cancer treatment. ScienceDaily . Retrieved March 24, 2025 from www.sciencedaily.com / releases / 2025 / 03 / 250303191502.htm ...