A novel class of DNA-binding domains has been established from at least sixteen recently identified DNA-binding proteins. The three-dimensional structure of one of these domains, Mrf-2, has been ...

A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

SMC (structural maintenance of chromosomes) protein complexes are ring-shaped molecular motors essential for genome folding. Despite recent progress, the detailed molecu ...

More information: Raktim Mitra et al, Geometric deep learning of protein–DNA binding specificity, Nature Methods (2024). DOI: 10.1038/s41592-024-02372-w Journal information: Nature Methods ...

The tool, called Deep Predictor of Binding Specificity (DeepPBS), is a geometric deep learning model designed to predict protein–DNA binding specificity from protein–DNA complex structures.

Link between DNA-protein binding, cancer onset identified. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2018 / 10 / 181025142028.htm. Stanford Medicine.