Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For ...

Within the NTase domain is an adenylate binding pocket composed of the six peptide motifs (I, Ia, III, IIIa, IV, and V) that define the covalent nucleotidyltransferase enzyme superfamily that includes ...

One distinct feature of transcription factors is that they have DNA-binding domains that give them the ability to bind to specific sequences of DNA called enhancer or promoter sequences.

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

A typical TF has multiple functional domains, not only for recognizing and binding to the appropriate DNA strand, but also for interactions with other TFs, with proteins called coactivators ...

By elucidating the role of the HNH nuclease domain and revealing the structural changes that occur upon DNA binding, this work not only deepens the understanding of CRISPR-Cas5-HNH but also paves ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.