By fusing various versions of the Gal4 AD to a DNA-binding domain and measuring the extent to which these fusion proteins activated gene expression, they identified a 31-residue disordered minimal AD ...

Preliminary scientific report. Esra Oktay, Farhang Alem, Keziah Hernandez, Aarthi Narayanan, Remi Veneziano. (2022). DNA Origami Presenting the Receptor Binding Domain of SARS-CoV-2 Elicit Robust ...

Ligands for therapeutics. The estrogen receptor (ER) is a ligand-inducible transcription factor that is comprised of a central DNA binding domain, a disordered N-terminal activation function 1 ...

AlphaGenome scores mutation effects across coding and non-coding DNA, bringing gene insights to the base-pair level.

Transcription factors are comprised of DNA binding domains and activation domains (ADs). Together, these domains create a bridge between the target gene and coactivators which are molecules that can ...

DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Science Translational Medicine , 2021; 13 (616) DOI: 10.1126/scitranslmed.abj1008 Cite This Page : ...

Thus, drugs that inhibit AR activity via domains other than the LBD may provide a way to inhibit the growth of drug-resistant PC. We discovered the first non-competitive, ligand-independent AR ...