One distinct feature of transcription factors is that they have DNA-binding domains that give them the ability to bind to specific sequences of DNA called enhancer or promoter sequences.

They explored combinations of various polymerases and DNA binding domains, focusing on structural motifs from nature. They were particularly drawn to features of T7 DNA polymerase—derived from the T7 ...

By elucidating the role of the HNH nuclease domain and revealing the structural changes that occur upon DNA binding, this work not only deepens the understanding of CRISPR-Cas5-HNH but also paves ...

Ian Small, a plant scientist at the University of Western Australia who was not involved in the research, writes in an email to The Scientist. Regular TALENs are composed of a DNA binding domain that ...

Within the NTase domain is an adenylate binding pocket composed of the six peptide motifs (I, Ia, III, IIIa, IV, and V) that define the covalent nucleotidyltransferase enzyme superfamily that includes ...

Several zinc ions are bound to the amino acid chain in the DNA-binding domain. This forms loops as a result (‘zinc fingers’) which can bind to DNA. Each zinc finger recognizes a characteristic ...

Figure 1: Three-dimensional structure of the Runt domain and its interaction with the β subunit. Figure 4: Mapping of the β heterodimerization surface of the RD onto the three-dimensional structure.