We often take facts we learn — like the fact that transcription factors bind to DNA — for granted. Or maybe not. See how researchers used DNA footprinting and gel shift assays to prove this idea.

DNA (deoxyribonucleic acid ... identifying 86 G4RPs and validating five of them through an in vitro binding assay.

A nanotransponder measuring just 250 x 250 x 100 µm (less than 1/1000th the size of a grain of rice) is the newest DNA microchip in PharmaSeq's family of microtransponders. Competitive devices are ...

To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic ... Following reversal of the crosslinks, they analyzed the DNA fragments using a dot blot ...

Scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein ...

For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously "undruggable" cancer protein target, permanently blocking it.

Adaptive Biotechnologies (ADPT) has launched an upgraded version of its clonoSEQ assay for measurable residual disease detection in diffuse ...

The research-use-only assay, which includes a qPCR detection kit and an isolation kit for cell-free DNA and exosomal RNA ... was designed to detect 11 ESR1 ligand-binding domain mutations in ...

Using a point-mutation strategy, researchers revealed that Mg 2+ is essential for the complex's DNA cleavage activity. Knock-in mice carrying a SPO11 point-mutation that disrupts Mg 2+ binding ...