It is surprising, then, to find that many DNA-binding proteins can bind more tightly to sequences that have been engineered to contain a type of single-nucleotide change called a mismatch.

DNA-binding proteins are proteins that bind to single- or double-stranded DNA, generally in the major groove if the binding is sequence-specific – as with transcription factors that regulate ...

The tool, called Deep Predictor of Binding Specificity (DeepPBS), is a geometric deep learning model designed to predict protein-DNA binding specificity from protein-DNA complex structures.

The tool, called Deep Predictor of Binding Specificity (DeepPBS), is a geometric deep learning model designed to predict protein–DNA binding specificity from protein–DNA complex structures.

"But if the protein stays there forever, then the gene editing process cannot be completed," Hall said. Examining the precise, molecular-level mechanisms involved in Cas binding to DNA, Wang and ...

The iMolecule group from Skoltech has developed an artificial intelligence-driven solution that uses data on the structure of RNA or DNA ... proteins or proteins that lack convenient binding ...

Developing drugs can be hit or miss, but now a tiny, DNA-based sensor ... if a prospective drug is binding to its target or reveal other cellular activity. Cells use protein molecules to ...

"But if the protein stays there forever, then the gene editing process cannot be completed," Hall said. Examining the precise, molecular-level mechanisms involved in Cas binding to DNA, Wang and ...