A research team has unveiled the cause and molecular mechanism of chronic brain inflammation that results in repetitive ...

TWEAK (tumour necrosis factor (TNF)-like weak inducer of apoptosis) is a member of the TNF superfamily of structurally related cytokines. It is present on the cell surface but a soluble form can ...

“Identifying where and how cytokine receptors work in the brain, we have begun to unravel the complex relationship between the nervous and immune systems in the effect of this complex crosstalk ...

JAMA study confirms that vaccines measurably alter menstrual cycle timing, offering direct evidence of neuroendocrine effects ...

Recent research published in PLOS One revealed a key mechanism driving acute to chronic muscle pain and demonstrated how ...

To send messages, cytokines bind to receptors on their target immune cells, much like a key fitting into a lock, to fulfill their role in the immune system. Interestingly, cytokines don't only ...

Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors and positive-feedback loops with corresponding transcription factors, as key mediators of both ...

Cytokines are well-known players in the immune response, helping to control inflammation and coordinate the responses of other immune cells. However, a growing body of evidence suggests that some ...

“One of the ways the immune system is doing that is to use cytokines, secreted factors, to go to the brain as communication tools.” The researchers found that the same BLA neurons that have receptors ...

IL17 is part of a cytokine family that includes five other members: IL17B, IL17C, IL17D, IL17E/IL25 and IL17F. The sequences of IL17 and IL17F are the most similar. To signal through the receptor ...

Discovery of innate immune receptor "brake" Siglec-E offers a novel therapeutic target to prevent organ transplant rejection ...