News
Cytokine traps block cytokine action in vivo. We first evaluated the in vivo activity of the human IL-1 trap by testing its ability to block the biological actions of human IL-1β administered SC ...
During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...
Cytokine actions may be autocrine meaning the cytokine acts on the same cell that secretes it. If the cytokine acts on cells nearby other than the one that secreted it, the action is termed paracrine.
Agents that block the action of specific cytokines have changed the lives of many patients with rheumatoid arthritis and other autoimmune disorders. But frequent self-injections or injections by a ...
This action elicits a further increase in neuronal APP expression and induces the expression of interleukin-23 and interleukin-12, two other proinflammatory cytokines that share a common subunit p40.
Cytokines are a diverse group of small protein molecules that play crucial roles in the immune system and various biological processes. They are synthesized and secreted by a range of immune cells, ...
Hundreds of cytokines are released when the immune system goes into action. They drive and suppress one another in complex feedback loops. “You take this thing like spaghetti that is connected ...
Cytokine release syndrome is an immune system response that can occur due to immunotherapy or infection. It happens when an immune system communication protein called cytokine is overproduced.
Cytokines are powerful regulators of the immune system and attractive therapeutic effector candidates. However, their sites of action must be restricted to avoid systemic toxicity.
Cytokine interaction networks drive immune function, but they are difficult to map and study. Not only are these networks complex, but they are built by molecules that typically exist in low ...
Expert Rev Endocrinol Metab. 2008;3(2):147-159. Inflammatory or immunological factors appear to be implicated in insulin resistance and decreased β-cell function. [37] Compared with nondiabetic ...
Get Instant Summarized Text (Gist) Incorporating interleukin-12 (IL-12) into mRNA vaccines enhances CD8 + T cell responses, improving protection against SARS-CoV-2, influenza, melanoma, and ...
Results that may be inaccessible to you are currently showing.
Hide inaccessible results