Cytokine traps block cytokine action in vivo. We first evaluated the in vivo activity of the human IL-1 trap by testing its ability to block the biological actions of human IL-1β administered SC ...

During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

A major subset of cytokines includes those that signal through Janus kinases (JAKs) and signal transducers and activators (STATs). These cytokines include (but are not limited to) interferons ...

Cytokine actions may be autocrine meaning the cytokine acts on the same cell that secretes it. If the cytokine acts on cells nearby other than the one that secreted it, the action is termed paracrine.

Cytokines are a diverse group of small protein molecules that play crucial roles in the immune system and various biological processes. They are synthesized and secreted by a range of immune cells, ...

One cytokine, two platforms. Synthekine aims to optimize IL-10, ... “Based on emerging external and internal data about non-alpha IL2’s mechanism of action and therapeutic potential, ...

Cytokines are powerful regulators of the immune system and attractive therapeutic effector candidates. However, their sites of action must be restricted to avoid systemic toxicity.

Cytokine release syndrome is an immune system response that can occur due to immunotherapy or infection. It happens when an immune system communication protein called cytokine is overproduced.

Expert Rev Endocrinol Metab. 2008;3(2):147-159. Inflammatory or immunological factors appear to be implicated in insulin resistance and decreased β-cell function. [37] Compared with nondiabetic ...

Cytokine Release Syndrome Diagnosis. Because CRS is usually caused by an infection or immunotherapy treatment, your doctor will likely do a lot of tests to find out whether you have CRS – and ...

The surprising synergy in KRAS G12V samples with combination therapy and the important synergistic change in cytokine patterns suggests potential strong immune stimulatory anti-cancer effects of ...