(A) Collagen IV α3, α4, and α5 normally form trimers and become constituents of the basement membrane in the kidney. In Alport Syndrome, genetic mutation in one of the chains disrupts trimer ...

Caption (A) Expression of collagen IV alpha-3, alpha-4, and alpha-5 in cells. High luminescence was produced only in the formation of the alpha-345 trimer. (B) Mutant alpha-5 proteins reported in ...