It forms part of a wider project (Sc2.0) that has now successfully synthesised all 16 native chromosomes in Saccharomyces cerevisiae, common baker’s yeast, and aims to combine them to form a fully ...
Yeast, a single-cell microorganism, typically has 16 chromosomes. Using a synthetic biological technique, Yuan’s team has designed and synthesized an extra yeast chromosome in a live cell.
Instead of the linear chromosomes found in mammals, the team crafted a circular chromosome, which is compatible with DNA replication in yeast. They then assembled the HAC inside budding yeast. By ...