Each of us has enough DNA to reach from here to the sun and back, more than 300 times. How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a ...

The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.

The team’s first target is cancer. Through the nanoimaging technologies, researchers discovered that the packing density of chromatin in cancer produced predictable changes in gene expression. In ...

Alternatively, packing of sperm chromatin may serve to reprogram the paternal genome so that the appropriate genes from the father's chromosomes are expressed in the early embryo. Whereas most ...

Packaging issues are associated with many serious ... In their new study, the researchers examined the spatial organization of chromatin, which includes DNA and related structural proteins ...

Dr. Toshio “Toshi” Tsukiyama studies how cells regulate chromatin, the packaging proteins responsible for compressing several feet of DNA inside each cell’s tiny nucleus. This genetic material needs ...

My research program is focused on understanding epigenetic mechanisms that govern higher order brain function via chromatin packaging in neurons.