The modification state helps determine whether the nucleosome is an appropriate substrate for a remodeler complex (Saha et al., 2006), as discussed later in this article. Chromatin structure is ...

Epigenetic reprogramming holds promise for reversing aging, addressing cellular aging mechanisms and paving the way for ...

Interestingly, 10 of the 60 genes implicated in the current study are involved in chromatin modification. These include mutations in genes that encode enzymes that covalently modify histone ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

He is learning how chromatin modifications influence important biological events within the cell’s nucleus and, in turn, how they affect development, aging and cancer formation. He also applies this ...

The chromatin landscape integrates diverse cellular signals to regulate genome structure and subsequent biological functions, partly through posttranslational modifications (PTMs) on histone proteins.

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

Histone modifications alter the structure of chromatin, affecting how tightly the DNA is packaged and influence gene expression. Similarly, transcription factors, which bind to the DNA, are essential ...

Chromatin is the physiological state of the genome ... A major, but not exclusive focus of our lab is the analysis of histones, their variants, post-translational modifications and proteoforms.

Inside every human cell, 2 meters of DNA must be tightly packed into a tiny nucleus. This DNA is wrapped around proteins to form chromatin, which exists in two main forms: euchromatin, where genes ...

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact ...