The principal epigenetic mechanisms by which tissue-specific gene-expression patterns and global gene silencing are established and maintained are chromatin modification — including processes ...

We give a general description of chromatin marks that are known to coexist spatially and describe the experimental technologies used to establish these findings. Patterns of these modifications ...

Chromatin Modifications Chromatin modification is achieved by covalent histone modifications and nucleosome modifications. Histone acetylation, deacetylation, methylation, and phosphorylation are ...

"The number of chromatin modifications known to exist in vivo is astronomical," Dann said. Not only did the experiments reveal that ISWI remodelers use the "acidic patch" to remodel chromatin ...

The basic mechanism of chromatin remodeling depends on the three dynamic properties of nucleosomes: reconstruction, enzyme-induced covalent modification, and repositioning. Regarding ...

Epigenetic regulation of gene expression is mediated through alterations in the DNA methylation status, covalent modifications of core nucleosomal ... and clinical development of epigenetic and ...

This extensive coordination was quite surprising, much like a music conductor (i.e. genetic variant) directing all the performers (i.e. transcription factors, chromatin modifications) of a musical ...

These modifications, which include DNA methylation, histone modifications, chromatin remodeling, and RNA modifications, are crucial for maintaining cell identity, proliferation, and ...

Epigenetics is the study of inherited phenotypic changes caused by mechanisms other than mutations in the underlying DNA sequence. In mammalian cells, most of the chromatin—a complex of DNA ...

Inside cells, DNA mixes with proteins to form chromatin within the nucleus. Within chromatin, structures called packing domains form when chromatin fibers fold together. These chromatin packing ...

In this activity, students build a model showing that DNA is enclosed in a histone cushion to form chromatin, the basic component of a chromosome. They use the model to demonstrate one way that ...