The research could contribute to the development of more effective anti-aging treatments in the future. The body's aging ...

The modification state helps determine whether the nucleosome is an appropriate substrate for a remodeler complex (Saha et al., 2006), as discussed later in this article. Chromatin structure is ...

Epigenetic modifiers, enzymes that catalyze covalent modifications on chromatin, play a pivotal role in establishing stable states for gene expression and cellular identity. Mutations in these ...

The way the body ages could be more resilient than previously thought, a new study suggests.

These modifications increase chromatin accessibility, influencing growth, differentiation, and ion transport, with contrasting effects on normal and colorectal cancer cells. Study: Short-chain ...

Short-chain fatty acids (SCFAs) like propionate and butyrate are critical byproducts of dietary fiber digestion. These molecules do more than fuel the body—they directly influence gene expression and ...

Histones not only keep DNA organized, but also help regulate gene expression. How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell ...

Every cell in your body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These ...

A novel, freely available AI tool has cut the time it takes to determine chromatin structure from days to minutes. The 3D ...

The way the body ages could be more resilient than previously thought, a new study suggests.

Chromatin is the physiological state of the genome ... A major, but not exclusive focus of our lab is the analysis of histones, their variants, post-translational modifications and proteoforms.

Chromatin, the mix of DNA and protein that houses each cell's genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by ...