Yasui et al. analyzed extracts from the thymi of normal and knockout (SATB1-/-) mice and found that components of the NURD, CHRAC and ACF chromatin remodeling complexes co-purified with SATB1.

The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.

Chromatin structure is highly complex and impressively ... Here, the C terminus forms a globular domain that is packaged into the nucleosome. The other end of the histone is more flexible and ...

"If we look at the average chromatin structures in human cells and many other organisms, we will see that chromosomes seem to be folded into clusters called topologically associated domains," said ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on ...