Within chromatin, structures called packing domains form when chromatin fibers fold together. These chromatin packing domains are critical for regulating gene expression, DNA replication and ...

This study proposes a new mechanism by which Chd1 senses and responds to DNA unwrapping via EDBL engagement to suppress ...

Chromatin structure is highly complex and impressively ... Here, the C terminus forms a globular domain that is packaged into the nucleosome. The other end of the histone is more flexible and ...

In eukaryotes, genomic DNA is stored in the nucleus as nucleosomes, interacting with a set of proteins, forming a molecular complex called chromatin. The proper folding of the chromatin structure ...

A new study in Cell reveals that lamina-associated domains (LADs) in early mouse embryos are shaped by dynamic epigenetic ...

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on ...

The fusion protein binds to the LacO domains (1), and incorporates the specialized centromeric histone CENP-A into and along neighboring chromatin (2). In turn, the region of CENP-A-containing ...