Ronald Levy, Stanford University With this technology, IDEC Pharmaceuticals researchers identified a hybridoma (2B8) that recognized CD20 and then developed a chimeric antibody (C2B8). This chimeric ...

Transgenic mice allow researchers to create “humanized” mice with human equivalents of murine antibody-coding genes. High throughput production of chimeric antibodies with murine-constant regions and ...

How do antibody engineers select isotypes? IgG1 has been the most popular choice by far and was used for 13 approved chimeric, humanized or fully human antibodies (compared with only two instances ...

Novel therapies for multiple myeloma (MM), including chimeric antigen receptor T-cell and bispecific antibodies, extend lives but raise concerns about treatment costs and adherence, and they haven't ...

South Korea-based DAAN Biotherapeutics has entered a licensing agreement with GC Cell, granting the latter exclusive rights to leverage its antibody sequence in the chimeric antigen receptor T ...

a fully human anti-VEGF monoclonal antibody; HALPRYZA, a recombinant chimeric murine/human anti-CD20 monoclonal antibody; SULINNO, a fully human antiTNF-a monoclonal antibody; Pemazyre ...

The past decade in oncology has been marked by the rise of immunotherapy, which leverages the immune system to attack tumors. For many solid tumors, immune checkpoint inhibitors have supplanted ...

a fully human anti-VEGF monoclonal antibody; HALPRYZA, a recombinant chimeric murine/human anti-CD20 monoclonal antibody; SULINNO, a fully human antiTNF-a monoclonal antibody; Pemazyre ...

The human anti-mouse antibody (HAMA) reaction limits the therapeutic utility of mouse monoclonal antibodies. Humanization of mouse monoclonal antibodies by genetic engineering can improve the in ...

An international team of researchers co-led by UVA's Hui Li, PhD, looked at what are known as "chimeric RNA" in Chinese men and found both similarities and differences to those seen in Western men.