It binds to the side of pre-existing actin filaments, where it nucleates the growth of new filaments. The Arp2/3 complex is very highly conserved, like actin. All of your cells are chock full of ...

laying the groundwork for the development of gene therapy for sickle cell disease and beta thalassemia. This new Perturb-multiome approach enables researchers to systematically reveal how ...

BCMA is selectively induced at the time of plasma cell differentiation and is almost absent on immature and memory B cells (Avery et al., 2003; Chiu et al., 2007). The communication between BCMA ...

During normal development, insulin-expressing beta cells appear around embryonic day 13.5 (E13.5) in mice or week 8 and 9 post-conception in humans 2,3, but regulated GSIS has been observed only ...

"We believe we've now found the master switch that drives the maturation process." In the months before and after birth, an infant's heart cells undergo dramatic changes. The cells enlarge ...

Orvacabtagene autoleucel (orva-cel), a B-cell maturation antigen (BCMA)-directed CAR T cell therapy for patients (pts) with relapsed/refractory multiple myeloma (RRMM): update of the phase 1/2 EVOLVE ...