Orca Bio, a late-stage biotechnology company committed to transforming the lives of patients through high-precision cell therapy, today announced the appointment of senior leaders to support the ...

Orvacabtagene autoleucel (orva-cel), a B-cell maturation antigen (BCMA)-directed CAR T cell therapy for patients (pts) with relapsed/refractory multiple myeloma (RRMM): update of the phase 1/2 EVOLVE ...

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

A total of 17 patients were enrolled and received MCARH109 therapy. The maximum tolerated dose was identified at 150×10 6 CAR T cells. At the 450×10 6 CAR T-cell dose, 1 patient had grade 4 ...

"These cells' maturation is arrested in the embryonic stage, even when they've grown in a dish for a year or more," says Chulan Kwon, Ph.D. , an assistant professor of medicine and member of the ...

So B-cell maturation antigen is an evolving field where we have three ways of targeting this receptor, including the antibody direct conjugate, as well as the chimeric antigen receptor T-cell ...

Short-term IF boosts glucose homeostasis, but prolonged fasting in adolescence may impair β cell maturation—potentially linking chronic IF to type 1 diabetes risk. Study: Chronic intermittent ...

While current therapeutic options include chemotherapy and immunotherapy, this study opens new avenues for novel approaches aiming at restoring normal B cell maturation. The team, spearheaded by ...

Teclistamab is a T-cell–redirecting bispecific antibody that targets B-cell maturation antigen (BCMA). 11,12 In the MajesTEC-1 study, 63% of the patients had a response and 57% remained in ...

“We want to know how cells organize themselves into an embryo-like ... a more complete representation of what’s going on in early stages of development, and can capture the background,” Lodewijik said ...