To produce cannabinoids in yeast (Saccharomyces cerevisiae), UC Berkeley synthetic biologists first engineered yeast's native mevalonate pathway to provide a high flux of geranyl pyrophosphate ...

also plays a role in the regulation of the cannabinoid pathway. Consistent with this, Di Marzo et al found that obese db/db and ob/ob mice, ...

Chemically modifying a synthetic cannabinoid could enable scientists to capitalize on the body’s natural pain-killing pathway without evoking drug tolerance or psychoactivity. Read the paper ...

Agonists of the type 1 cannabinoid receptor (CB1 ... They also activate the β-arrestin signalling pathway, which is associated with side effects and tolerance. Rangari et al.

The drug, known as VIP36, targets the body's cannabinoid receptor type 1 (CB1 ... previous attempts to target this pathway have been met with two challenges. First, repeated exposure to a drug leads ...

A protein that acts as a cannabinoid receptor and is present in the structure controlling exchanges between the bloodstream and the brain could be part of the answer, according to a study ...

Researchers are attempting to spread awareness about that condition, cannabinoid hyperemesis syndrome (CHS), and the need for more government oversight in the legal cannabis industry. A rare but ...

Cannabis users with type 1 diabetes (T1D) can be misdiagnosed with diabetic gastroparesis on the basis of symptoms or presentation with or without gastric emptying tests; however, cannabinoid ...

Journavx's main ingredient works by targeting a pain-signaling pathway that involves sodium ... He said a synthetic cannabinoid molecule that avoids binding to the high-producing CB1 nerve cell ...