Mammary gland fibroblasts are highly plastic and transition through distinct states during development and disease. A new ...

Since the application of molecular biology in cancer ... Hypoxia causes suppression of anticancer immunity on NSCLC through direct effects on lymphocytes and indirectly by tuning tumor-associated ...

Researchers have discovered a previously unknown type of connective tissue cells that surround cancer cells in pancreatic tumors. The newly discovered cells counteract tumor development and may ...

The study focused on fibroblasts, cells that comprise connective tissue and secrete collagen. One subtype of fibroblasts, cancer-associated fibroblasts (CAFs), play a pivotal role in promoting tumor ...

The study presented here demonstrates this impairment by successfully identifying a relationship between cancer-associated fibroblasts (CAF) and T cells. The team was required to perform spatial ...

CAFs Impact ECM and tumor growth: CAFs secrete MMPs to degrade ECM, releasing growth factors for cancer cells. ECM changes counteract CAFs and tumor cells: (a) Hard ECM triggers Twist release from ...

Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression, and how these stromal mechanisms affect cell fate and ...

Researchers at Umeå University, Sweden, have discovered a previously unknown type of connective tissue cells that surround ...