Many patients do not respond well to immunotherapy, said Professor Gareth Thomas, who led the study and has been examining the types of cells that surround tumors—cancer-associated fibroblasts ...

Chemokines, our body's chemical messengers, play a crucial role in regulating the immune response.  They are secreted by ...

Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates—only 10% after five years. One of the factors contributing to its aggressiveness is its tumor ...

Cancer-associated fibroblasts (CAFs) are an important component in solid tumors. They play a decisive role in cancer development and have a significant influence on the success of therapy. The ...

Study Identifies Subtypes of Fibroblasts in Skin Cancer Nov. 19, 2024 — A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes ...

Upon further analysis, the researchers observed that cancer-associated fibroblasts were producing these proteins. The evidence, they say, suggests that these proteins can contribute to suppression ...

Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression, and how these stromal mechanisms affect cell fate and ...

Here, she studied the mechanical role of cancer-associated fibroblasts in promoting breast cancer disease progression in the laboratories of Morag Park and Christopher Moraes. She joined Nature ...