Calpain expression is altered during tumorigenesis, and the proteolysis of numerous substrates, such as inhibitors of nuclear factor-κB (IκB), focal adhesion proteins (including, focal adhesion ...

Some calpain ... calpains to their substrates, rather than promote autolysis. 16–23 μ-Calpain and m-calpain have diverse functions. 11,32 They catalyze the proteolysis of proteins involved ...

The late stages of muscle development turn out to be driven by a protein-degradation process that is usually ... There might be more transcription factors to be found as the substrates of calpain-5.

"We have an interest in this protein because it's important for Plasmodium development," he explains. "We initially found that calpain played a role in parasites being able to get out of their ...

Further understanding of the role of this protein, calpain 14, may lead to potential therapies for EoE. The researchers received support from the National Institute of Allergy and Infectious ...

The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. Oncotarget , 2014 ...

Blocking that protein, called calpain, in the lungs may prove an effective way to avoid narrow, scarred blood vessels and pulmonary hypertension, said Dr. Yunchao Su, pharmacologist at Georgia ...

Further understanding of the role of this protein, calpain 14, may lead to potential therapies for EoE. The researchers received support from the National Institute of Allergy and Infectious ...

Optimized for detecting calpain activity, this kit contains a novel internally quenched 5-FAM/QXL™ 520 FRET substrate. Cleavage of this FRET substrate generates two separate fragments. The subsequent ...

The study, led by academics at The University of Nottingham and published online by the academic journal Oncotarget, discovered that when high levels of the protein calpain were detected in large ...