there are several potential disadvantages in comparison with CRISPR/Cas9 system. For example, there is no straightforward and easy way to construct zinc finger domains to bind a comprehensive ...

The CRISPR-Cas system has significantly improved over traditional gene editing techniques, such as transcription activator-like effector nuclease and zinc-finger nucleases, by providing an easily ...

“I think this system levels the playing field for zinc fingers and CRISPR,” said Kim, who is also a professor of molecular genetics and computer science at U of T. “CRISPR is very ...

Ichikawa notes that zinc-finger editing offers a potentially safer alternative to CRISPR, a key gene-editing technology with applications that range from finding new ways to kill cancer cells to ...

Scientists have long seen their potential because they naturally bind with DNA, are less likely than CRISPR and related technologies to trigger an immune reaction, and are small enough to work with ...

The researchers used CRISPR and zinc fingers to repress NaV 1.7 and block pain signals in neurons in mice. Credit: A.M. Moreno et al., Science Translational Medicine (2021) “In managing any ...

such as zinc finger nuclease (ZFN) systems and transcription activator-like effector nuclease (TALEN) systems. Indeed, the use of CRISPR platforms can result in off-target modifications ...

Scientists have long seen the potential of zinc finger proteins because they naturally bind with DNA, are less likely than CRISPR and related technologies to trigger an immune reaction, and are small ...