there are several potential disadvantages in comparison with CRISPR/Cas9 system. For example, there is no straightforward and easy way to construct zinc finger domains to bind a comprehensive ...

But zinc fingers, which cost US$5,000 or more to order, were not widely adopted because they are difficult to engineer and expensive, says James Haber, a molecular biologist at Brandeis University in ...

The CRISPR-Cas system has significantly improved over traditional gene editing techniques, such as transcription activator-like effector nuclease and zinc-finger nucleases, by providing an easily ...

And there’s a bit of a misconception that the prior generations are inferior to CRISPR technology: In reality, they may offer some advantages. “I would say that zinc finger nucleases ...

Ichikawa notes that zinc-finger editing offers a potentially safer alternative to CRISPR, a key gene-editing technology with applications that range from finding new ways to kill cancer cells to ...

Scientists have long seen their potential because they naturally bind with DNA, are less likely than CRISPR and related technologies to trigger an immune reaction, and are small enough to work with ...

Gang Bao, a biochemical engineer at Rice University, is working on a treatment for sickle cell disease using CRISPR.Credit...Rice University In the beginning there was zinc finger nuclease.

such as zinc finger nuclease (ZFN) systems and transcription activator-like effector nuclease (TALEN) systems. Indeed, the use of CRISPR platforms can result in off-target modifications ...