Mayo Clinic's Precision Mouse Engineering Core in Minnesota produces CRISPR/Cas9-mediated knockout and point mutant mice for researchers.

A minimum of 3 positive founders will be delivered. To produce CRISPR/cas9-mediated gene indels to generate knock-out mice or rats. The investigator will provide or purchase the CRISPR gRNA(s). TGEF ...

(REUTERS) British scientists are testing cutting edge gene editing techniques in mice, by inserting a jelly fish gene that makes their skin green. The research uses CRISPR-Cas9, a gene editing ...

The precise insertion of DNA sequences using the homology-directed repair (HDR) pathway is one potential use of the CRISPR/Cas genome editing technology. Various circumstances could influence the ...

R esearchers at Beijing's Chinese Academy of Sciences have used the gene-editing technology CRISPR to create mice from two fathers. CRISPR is a powerful genetic editing tool that allows scientists ...

“It shows that CRISPR-mediated gene editing can lead to real amelioration of hearing loss in vivo.” The so-called Beethoven mouse model has the same point mutation in the mouse version of Tmc1 that in ...

The paper L. Jubair et al., “Systemic delivery of CRISPR/Cas9 targeting HPV oncogenes is effective at eliminating established tumors,” Mol Ther, 27:2091–99, 2019. When the human papillomavirus enters ...

Now, an in vivo protocol facilitates screens in mouse ... of the CRISPR guide RNAs. Exploration of dsRNA interactome using the K1 antibody and functional studies using CRISPR-Cas9 knockout ...

This study presents an enhanced nuclease prime editor (uPEn) that significantly improves gene knock-in and knockout ...