CRISPR-Cas9 is a reprogrammable DNA cutting machine that is being used to edit genomes in many organisms for research purposes. Its primary component, the Cas9 enzyme (orange), cuts genomic DNA ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

CRISPR-Cas9 is a tool that allows scientists to swap a particular, potentially faulty gene with another, potentially healthy one. It sets itself apart from other gene-editing techniques ...

A visual description of the CRISPR/Cas9 research explored by UNT researchers using TACC supercomputers. Simulations found that Cas9 produces staggered, "sticky" ends, which may make them easier to ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume ...

2 To find out whether base editors were truly less error-prone than CRISPR-Cas9 tools, the team compared their DNA editing performance. They chose to target the gene for β2-microglobulin because it ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

A team of researchers from the Innovation Center of NanoMedicine (Kawasaki, Japan) has successfully used nano-micelles for the delivery of CRISPR-Cas9 tools to the functional brain tissue of ...