In a groundbreaking achievement, doctors have successfully treated a baby boy with a life-threatening genetic disorder using ...

Scientists have bred spiders that weave red draglines, proving that the animals’ silk can be genetically re-engineered.

In a world first, scientists used CRISPR to fix a baby's unique genetic mutation. The report offers hope for personalized ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

The University of Bayreuth's Biomaterials research group has, for the first time, successfully applied the CRISPR-Cas9 ...

G ene therapy has always held enormous promise to correct genetic diseases, but turning that potential into treatments has ...

Base-editing technologies along with AAV engineering not only help reduce costs but can also accelerate preclinical ...

Scientists were able to create a bespoke treatment for KJ Muldoon’s rare genetic disorder within six months. It could be a ...

In a new study published in Nature titled, “Custom CRISPR-Cas9 PAM variants ... used Streptococcus pyogenes Cas9 (SpCas9), pairing requires the standard PAM sequence, 3’NGG, which inevitably ...

Get Instant Summarized Text (Gist) A machine learning algorithm, PAMmla, was developed to predict properties of about 64 million genome-editing enzymes, enabling the design of CRISPR-Cas9 variants ...

Researchers used machine learning to predict the PAMs of millions of Cas9 enzymes, identifying a set of novel engineered Cas9 enzymes that would have the best on-target activity and specificity.