This will allow quicker and easier gene knock-down experiments, for example, because having on-board Cas9 makes more room in vectors ... No longer will researchers seeking to mouse lines that model ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... Here, the authors present the generation and validation of a Cas12a transgenic mouse model. Additionally, the authors create whole-genome ...

In a preprint posted to bioRxiv last week (July 4), researchers at the University of California, San Diego, report using a CRISPR-Cas9 gene drive in mammals for the first time. Gene drives ensure that ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...

Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.