Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... Here, the authors have designed and optimized circular guide RNA (cgRNA) for Cas12f, which significantly improves the efficiency of gene ...

This protein can easily be programmed to find and bind to almost any desired target sequence, simply by giving it a piece of RNA to guide it in its search. When the CRISPR Cas9 protein is added to ...

With CRISPR-Cas9, the crRNA/tracrRNA sequence or an artificial guide RNA indicate where the DNA can be cut. It is relatively easy for scientists to produce different sequence variants from RNA ...

ERS Genomics (ERS), which was established to provide broad access to the foundational CRISPR/Cas9 intellectual ... claims covering single guide RNAs, modified DNA-targeting RNAs and the combination ...

Over the years, scientists have explored alternatives to Cas9, such as Cas12a for more precise multigene editing, a type III CRISPR for RNA editing, and a Cas13 loaded with multiple guide RNAs for ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

The method may allow researchers to edit more types of genetic mutations than existing genome-editing approaches such as CRISPR-Cas9, researchers report today (October 21) in Nature. Emma Haapaniemi, ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have ... which allows scientists to use a "guide" RNA to modify DNA sequences and evaluate the effects—is ...